Understanding how serotonin receptor 7 affects immune tolerance in the gut
Official title: Identifying the role of serotonin receptor 7 in regulating intestinal immune tolerance
Funded at University of California Los Angeles · NIH-10826770 · Data updated 2026-11-12
This study is looking at how a specific serotonin receptor in the gut helps keep our immune system balanced and healthy by working with certain gut bacteria, which could lead to new ways to improve gut health and treat digestive issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $44,646 |
| NIH project number | 1F31AI174799-01A1 |
| Project ID | NIH-10826770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with gastrointestinal disorders or those interested in the relationship between gut microbiota and immune health.
✕Less likely to help
Patients with non-gastrointestinal related health issues may not receive direct benefits from this research.
What this research studies
This research investigates the role of serotonin receptor 7 in the gut's immune system, focusing on how it helps maintain a healthy balance between the host and gut microbiota. By examining the interactions between specific gut microbes, like Bacteroides fragilis, and immune cells, the study aims to uncover the molecular mechanisms that promote immune tolerance. Patients may benefit from insights into how gut health influences overall immune function and could lead to new therapeutic strategies for gastrointestinal disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to gut health and immune responses.
How similar studies have gone: Previous research has shown promising results in understanding gut microbiota interactions and immune tolerance, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Yu, Lewis — University of California Los Angeles
- Study coordinator: Yu, Lewis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.