Understanding how serotonin changes contribute to involuntary movements in Parkinson's disease treatment.
Interrogating Maladaptive Serotonin Raphe-Striatal Plasticity in L-DOPA-Induced Dyskinesia
This study is looking at how certain brain cells that use serotonin might be causing the unwanted movements some people with Parkinson's experience after taking L-DOPA, and it's for anyone with Parkinson's who wants to learn more about new ways to manage these movements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project ID | NIH-10991033 on NIH RePORTER |
What this research studies
This research investigates the role of serotonin neurons in causing involuntary movements known as L-DOPA-induced dyskinesias (LID) in patients with Parkinson's disease. By examining how these neurons adapt and reorganize in response to L-DOPA treatment, the research aims to uncover the underlying mechanisms that lead to these debilitating movements. The team is utilizing innovative approaches to gather data that could reveal new insights into the neuroplasticity of serotonin pathways and their impact on motor control. Ultimately, the goal is to identify potential new treatments that could prevent or reduce LID in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are currently receiving L-DOPA treatment and experiencing involuntary movements.
Not a fit: Patients who are not undergoing L-DOPA treatment or those with Parkinson's disease who do not experience involuntary movements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or alleviate involuntary movements in Parkinson's disease patients treated with L-DOPA.
How similar studies have performed: While the specific mechanisms being investigated are novel, previous research has shown that understanding neuroplasticity can lead to significant advancements in treating movement disorders.
Where this research is happening
Binghamton, United States
- State University of Ny,binghamton — Binghamton, United States (Active)
Researchers
- Principal investigator: Bishop, Christopher R — State University of Ny,binghamton
- Study coordinator: Bishop, Christopher R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.