Understanding how serotonin affects the body and how drugs interact with it
Structural Studies and Drug Discovery Illuminate Serotonin Pharmacology
This study is looking into how serotonin affects things like mood and heart health, and it aims to find out how different medications can work better by understanding how serotonin functions in the body, which could help patients feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11144918 on NIH RePORTER |
What this research studies
This research investigates the complex role of serotonin in regulating various physiological functions, including mood, cognition, and cardiovascular health. By using advanced structural and biochemical techniques, the team aims to uncover how serotonin receptors and transporters work at a molecular level and how different medications can influence these processes. Patients may benefit from a deeper understanding of how existing and new drugs can be optimized for better therapeutic outcomes related to serotonin signaling.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with mood disorders, cardiovascular issues, or those interested in the effects of serotonergic medications.
Not a fit: Patients who do not have any serotonin-related conditions or are not taking serotonergic medications may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to serotonin dysfunction, such as depression and cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding serotonin signaling, but this project aims to provide novel insights that have not been fully explored.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Wacker, Daniel — Icahn School of Medicine at Mount Sinai
- Study coordinator: Wacker, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.