Understanding how serotonin affects gut pain and movement
The role of mucosal serotonin in visceral nociception and gut motility
This study is looking at how serotonin in your gut affects pain and movement, especially for people with irritable bowel syndrome (IBS), to find new ways to help manage symptoms with fewer side effects.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10898725 on NIH RePORTER |
What this research studies
This research investigates the role of serotonin in the gut, particularly how it influences pain and motility in conditions like irritable bowel syndrome (IBS). It aims to explore the mechanisms by which serotonin signaling affects gut function and how modifying this signaling could lead to better treatments for IBS. The study focuses on the cells in the gastrointestinal tract that produce serotonin and how they interact with nerve cells to regulate gut sensations and movements. By gaining insights into these processes, the research seeks to identify new therapeutic strategies that minimize side effects associated with current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals, both children and adults, who are diagnosed with irritable bowel syndrome.
Not a fit: Patients with gastrointestinal disorders unrelated to serotonin signaling or those without a diagnosis of irritable bowel syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients suffering from irritable bowel syndrome.
How similar studies have performed: Previous research has shown that targeting serotonin signaling can have therapeutic potential, but this specific approach focusing on mucosal serotonin is relatively novel.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Najjar, Sarah — New York University
- Study coordinator: Najjar, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.