Understanding how serotonin affects energy production in diabetes, depression, and dementia
Serotonin modulated mitochondrial dysfunction in Depression Diabetes and Dementia (3Ds)
This study is looking at how low serotonin levels might affect energy production in people with diabetes, depression, and Alzheimer's disease, and it will also test if a common medication can help improve their health and well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10766747 on NIH RePORTER |
What this research studies
This research investigates the relationship between serotonin levels and mitochondrial function in patients with diabetes, depression, and dementia, particularly Alzheimer's disease. It aims to uncover how low serotonin may lead to mitochondrial dysfunction, which can worsen cognitive and physical health. The study will explore the potential of selective serotonin reuptake inhibitors, like citalopram, to improve mitochondrial health and overall patient outcomes. By examining these connections, the research seeks to provide insights into better treatment strategies for these interconnected conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetes, depression, and/or dementia, particularly Alzheimer's disease.
Not a fit: Patients without any of these conditions or those who do not respond to serotonin-modulating treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from diabetes, depression, and dementia, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of serotonin in mental health and metabolic disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Lubbock, United States
- Texas Tech University — Lubbock, United States (Active)
Researchers
- Principal investigator: Hegde, Vijay Karkal — Texas Tech University
- Study coordinator: Hegde, Vijay Karkal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.