Understanding how serotonin affects brain processing
CRCNS: A mechanistic theory of serotonergic modulation of cortical processing
['FUNDING_R01'] · UNIVERSITY OF OREGON · NIH-10870224
This study is looking at how a brain receptor related to serotonin affects how we see and understand things around us, especially for people with conditions like schizophrenia, to help improve our understanding of how serotonin influences our perception and mental health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-10870224 on ClinicalTrials.gov |
What this research studies
This research investigates how the serotonin-2A receptor influences sensory perception by integrating external stimuli with internal expectations and behavioral states. It aims to clarify the complex effects of serotonin on neural circuits, particularly in relation to visual processing and conditions like schizophrenia. By combining theoretical models with experimental data, the study seeks to reconcile conflicting observations about serotonin's role in brain function. Patients may benefit from insights into how serotonin modulation affects their perception and mental health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing affective disorders or schizophrenia who may be affected by serotonin modulation.
Not a fit: Patients with conditions unrelated to serotonin modulation or those not experiencing perceptual alterations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for affective disorders and conditions like schizophrenia by enhancing our understanding of serotonin's role in perception.
How similar studies have performed: Previous research has shown promising results in understanding the effects of serotonin on brain function, particularly in relation to psychedelics and mental health conditions.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAZZUCATO, LUCA — UNIVERSITY OF OREGON
- Study coordinator: MAZZUCATO, LUCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders