Understanding how serotonin affects brain cell development using human-derived models
Investigating the role of serotonergic signaling in glial development using human iPSC-derived organoids
This study is looking at how serotonin affects the growth and health of brain support cells called astrocytes, which are important for keeping our brains functioning well, and it’s designed for anyone interested in understanding more about brain health and conditions related to it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10702094 on NIH RePORTER |
What this research studies
This research investigates the role of serotonergic signaling in the development of glial cells, specifically astrocytes, which are crucial for brain health. By utilizing human-induced pluripotent stem cell (iPSC)-derived organoids, the study aims to explore how serotonin influences the maturation and function of these cells. The approach involves examining the interactions between astrocytes and neurons, focusing on the effects of brain-derived neurotrophic factor (BDNF) on astrocyte morphology and function. This research could provide insights into neurodevelopmental disorders linked to BDNF dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who may be affected by neurodevelopmental disorders, particularly those associated with BDNF dysregulation.
Not a fit: Patients with fully developed neurological conditions or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders by enhancing our understanding of brain cell development.
How similar studies have performed: Previous research has shown promising results in understanding the role of BDNF in neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Hernandez, Raymundo Daniel — Emory University
- Study coordinator: Hernandez, Raymundo Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.