Understanding how sepsis and trauma affect blood cell production and immune response
Pathological Myeloid Activation After Sepsis and Trauma
This study is looking at how sepsis and severe injuries can affect patients over time, especially how they might lead to ongoing health issues, and it aims to find out more about certain immune cells that could help improve recovery for those who are struggling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11052531 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of sepsis and severe trauma on patients, particularly focusing on how these conditions can lead to chronic critical illness characterized by persistent inflammation and immune dysfunction. The study aims to identify the mechanisms behind the production of myeloid-derived suppressor cells (MDSCs), which are linked to poor recovery outcomes in patients. By analyzing blood samples and immune responses, the researchers hope to uncover new insights that could lead to better treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have experienced sepsis or severe trauma and are currently in surgical intensive care units.
Not a fit: Patients who have not experienced sepsis or trauma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for patients suffering from the long-term effects of sepsis and trauma.
How similar studies have performed: Previous research has shown promising results in understanding the role of myeloid-derived suppressor cells in sepsis and trauma, indicating that this approach has potential for significant advancements.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Efron, Philip a — University of Florida
- Study coordinator: Efron, Philip a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.