Understanding how sepsis affects the immune system over time
Cellular and molecular mechanisms controlling sepsis-induced immunoparalyses state
This study is looking at how sepsis can affect your immune system for a long time, especially how it can make you more vulnerable to infections even after you feel better, and it aims to find ways to help boost your immune health if you've survived sepsis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10765664 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of sepsis on the immune system, particularly focusing on a condition called immunoparalysis, which makes patients more susceptible to infections even after they recover from the initial sepsis. The study aims to identify the cellular and molecular changes in immune cells that occur after sepsis, particularly looking at lymphocyte populations. By understanding these mechanisms, the researchers hope to develop strategies to improve immune function and reduce the risk of infections in sepsis survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have survived sepsis and are experiencing ongoing immune system issues.
Not a fit: Patients who have not experienced sepsis or those with pre-existing immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis survivors, helping to restore their immune function and reduce their risk of subsequent infections.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in sepsis, but this specific focus on long-term immunoparalysis is relatively novel.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Badovinac, Vladimir P — University of Iowa
- Study coordinator: Badovinac, Vladimir P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.