Understanding how sepsis affects immune cells
CD4 T cell dysfunction and reprogramming during sepsis
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11082293
This study is looking at how sepsis affects important immune cells called CD4 T cells, to understand why they don’t work as well after recovery and to find ways to help improve health for people who have survived sepsis.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11082293 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of sepsis on CD4 T cells, which are crucial for the immune response. It aims to uncover how these cells are depleted during sepsis and how their function is impaired long after recovery. By examining the cellular and molecular changes in CD4 T cells, the research seeks to identify potential therapeutic targets to improve immune function in sepsis survivors. This could lead to better management of long-term health issues faced by these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced sepsis.
Not a fit: Patients who have not had sepsis or those with pre-existing immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance recovery and immune resilience in patients who have survived sepsis.
How similar studies have performed: Previous research has shown that understanding immune cell dysfunction in sepsis can lead to improved treatment strategies, indicating a promising avenue for this investigation.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRIFFITH, THOMAS S — UNIVERSITY OF MINNESOTA
- Study coordinator: GRIFFITH, THOMAS S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.