Understanding how sepsis affects immune cell development.
S100A9 and MDSC development in sepsis.
['FUNDING_OTHER'] · EAST TENNESSEE STATE UNIVERSITY · NIH-10594050
This study is looking at how certain immune cells called myeloid-derived suppressor cells (MDSCs) behave during sepsis, a serious condition that can weaken the immune system, and aims to find ways to boost the immune response and help people recover better from sepsis.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EAST TENNESSEE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (JOHNSON CITY, UNITED STATES) |
| Trial ID | NIH-10594050 on ClinicalTrials.gov |
What this research studies
This research investigates the role of myeloid-derived suppressor cells (MDSCs) in sepsis, a severe condition that can lead to persistent immune suppression and increased mortality. By using a mouse model, the study aims to uncover the molecular mechanisms behind chronic MDSC development and its contribution to sepsis-related complications. The researchers will explore specific proteins and genetic factors that may be targeted to improve immune function and survival rates in sepsis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced sepsis or are at high risk for developing sepsis.
Not a fit: Patients who do not have a history of sepsis or related immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune response and reduce mortality in patients suffering from sepsis.
How similar studies have performed: While targeting molecular mechanisms in sepsis has been challenging, this research proposes a novel approach that has not been extensively tested in previous studies.
Where this research is happening
JOHNSON CITY, UNITED STATES
- EAST TENNESSEE STATE UNIVERSITY — JOHNSON CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELGAZZAR, MOHAMED A. — EAST TENNESSEE STATE UNIVERSITY
- Study coordinator: ELGAZZAR, MOHAMED A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.