Understanding how sepsis affects heart metabolism
Regulation of Cardiac Metabolic Plasticity in Sepsis
['FUNDING_R21'] · LOYOLA UNIVERSITY CHICAGO · NIH-10629401
This study is looking at how a protein called PDK4 affects heart problems that can happen during sepsis, with the hope of finding new ways to help protect the heart for people who are dealing with sepsis.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-10629401 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, pyruvate dehydrogenase kinase 4 (PDK4), in how sepsis leads to heart problems. By studying both laboratory models and animal subjects, the research aims to uncover how PDK4 contributes to metabolic issues in the heart during sepsis. The goal is to identify new therapeutic strategies that could protect the heart from damage caused by sepsis. If successful, this could lead to better treatments for patients suffering from sepsis-related heart complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing sepsis, particularly those showing signs of heart dysfunction.
Not a fit: Patients with sepsis who do not exhibit cardiac issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function in patients with sepsis.
How similar studies have performed: Previous studies have shown promising results in targeting metabolic pathways in sepsis, suggesting that this approach could be effective.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZANG, QUN SOPHIA — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: ZANG, QUN SOPHIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.