Understanding how sepsis affects blood vessel function
The Physiology and Biochemistry of Sepsis-induced Vasoplegia
['FUNDING_CAREER'] · UNIVERSITY OF MINNESOTA · NIH-10984095
This study is looking at how blood vessels change during sepsis, a serious infection that can cause low blood pressure, to find better ways to protect patients' organs and improve treatments.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10984095 on ClinicalTrials.gov |
What this research studies
This research investigates the physiological and biochemical changes that occur in blood vessels during sepsis, a severe infection that can lead to dangerously low blood pressure. The study aims to understand how large and small blood vessels behave during this condition, which can result in organ damage. By using advanced techniques like microscopy and animal models, the research seeks to identify ways to mitigate the harmful effects of sepsis on the vascular system. This work is crucial for developing better treatments for patients suffering from sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who are experiencing severe hypotension and related complications.
Not a fit: Patients with sepsis who do not exhibit vasoplegia or those with other unrelated medical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce organ damage and enhance survival rates for patients with sepsis.
How similar studies have performed: Previous research has shown promise in understanding vascular responses in sepsis, but this specific approach using advanced techniques and animal models is relatively novel.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WISE, ERIC STEPHEN — UNIVERSITY OF MINNESOTA
- Study coordinator: WISE, ERIC STEPHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.