Understanding how sepsis affects blood vessel function
Official title: The Physiology and Biochemistry of Sepsis-induced Vasoplegia
Funded at University of Minnesota · NIH-10984095 · Data updated 2026-11-12
This study is looking at how blood vessels change during sepsis, a serious infection that can cause low blood pressure, to find better ways to protect patients' organs and improve treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $172,937 |
| NIH project number | 1K08HL171885-01A1 |
| Project ID | NIH-10984095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis who are experiencing severe hypotension and related complications.
✕Less likely to help
Patients with sepsis who do not exhibit vasoplegia or those with other unrelated medical conditions may not benefit from this research.
What this research studies
This research investigates the physiological and biochemical changes that occur in blood vessels during sepsis, a severe infection that can lead to dangerously low blood pressure. The study aims to understand how large and small blood vessels behave during this condition, which can result in organ damage. By using advanced techniques like microscopy and animal models, the research seeks to identify ways to mitigate the harmful effects of sepsis on the vascular system. This work is crucial for developing better treatments for patients suffering from sepsis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce organ damage and enhance survival rates for patients with sepsis.
How similar studies have gone: Previous research has shown promise in understanding vascular responses in sepsis, but this specific approach using advanced techniques and animal models is relatively novel.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Wise, Eric Stephen — University of Minnesota
- Study coordinator: Wise, Eric Stephen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.