Understanding how sensory receptors detect stimuli and their role in pain perception
Official title: Structure, function, and pharmacology of sensory receptors
Funded at Duke University · NIH-10665226 · Data updated 2026-11-12
This study is looking at how certain tiny channels in nerve cells help us feel things like temperature and pain, and it aims to find new ways to treat issues like chronic itch and migraines by understanding how these channels work and how they can be affected by genetic changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2032 |
| Funding year | 2024 |
| Award (this year) | $885,128 |
| NIH project number | 1R35NS132231-01 |
| Project ID | NIH-10665226 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from chronic pain conditions, such as migraines or chronic itch, particularly those with genetic mutations affecting sensory receptors.
✕Less likely to help
Patients with sensory disorders not linked to the specific receptor channels being studied may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms of sensory receptor ion channels in somatosensory neurons, which are crucial for detecting stimuli like temperature changes and irritants. By studying how these receptors transmit information to the spinal cord and brain, the research aims to uncover the integration of sensory signals and the impact of genetic mutations on sensory disorders. The team will employ a variety of methodologies, including structural and functional studies, to develop small molecules that can target these receptors, potentially leading to new treatments for conditions such as chronic itch and migraines.
Why it matters
Potential benefit: If successful, this research could lead to the development of non-opioid medications that effectively treat pain and sensory disorders.
How similar studies have gone: Previous research has shown promise in understanding sensory receptors and developing targeted therapies, indicating that this approach has potential for success.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Lee, Seok-Yong — Duke University
- Study coordinator: Lee, Seok-Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.