Understanding how sensory receptors affect movement in Angelman Syndrome
The Role of Sensory Receptors in Angelman Syndrome
This study is looking at how a specific protein called PIEZO2 affects movement and walking in people with Angelman Syndrome, hoping to find new ways to help improve their motor skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11030311 on NIH RePORTER |
What this research studies
This research investigates the role of sensory receptors, specifically the PIEZO2 ion channel, in individuals with Angelman Syndrome (AS), a neurogenetic disorder that leads to motor coordination issues and gait deficits. The study aims to uncover the molecular mechanisms behind these gait problems by examining how reduced PIEZO2 function in sensory neurons may contribute to the symptoms experienced by patients. By using mouse models and genetic data, the researchers hope to establish a link between PIEZO2 function and the motor challenges faced by those with AS, potentially paving the way for new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Angelman Syndrome who experience gait and coordination difficulties.
Not a fit: Patients without a diagnosis of Angelman Syndrome or those whose symptoms are unrelated to sensory receptor function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that improve motor coordination and balance for individuals with Angelman Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding sensory receptor functions in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Cordero-Morales, Julio F — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Cordero-Morales, Julio F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.