Understanding how sensory neurons and mast cells interact in irritable bowel syndrome
Sensory neuron-mast cell crosstalk in IBS pathophysiology
['FUNDING_R03'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11111516
This study is looking at how certain nerve cells and immune cells in the gut work together in people with irritable bowel syndrome (IBS) to cause symptoms like abdominal pain, with the hope of finding new ways to help manage the condition.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11111516 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between sensory neurons and mast cells in patients with irritable bowel syndrome (IBS), focusing on how these interactions contribute to abdominal pain and other symptoms. The study aims to uncover the mechanisms behind visceral hypersensitivity and barrier dysfunction, which are common in IBS. By examining the role of Substance P, a neuropeptide released by sensory neurons, the researchers will explore how it activates mast cells and affects gut health. This could lead to a better understanding of IBS and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D).
Not a fit: Patients with other gastrointestinal disorders or those not diagnosed with IBS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for abdominal pain in IBS patients.
How similar studies have performed: Previous research has indicated that understanding the role of mast cells and sensory neurons in gastrointestinal disorders can lead to significant advancements in treatment, suggesting a promising avenue for this investigation.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGH, PRASHANT — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: SINGH, PRASHANT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.