Understanding how sensory neurons affect inflammation
Official title: Functional interrogation of sensory neurons in inflammation
Funded at Scripps Research Institute, the · NIH-10890865 · Data updated 2026-11-12
This study is looking at how itch-sensing nerves in our body might affect chronic inflammatory diseases, with the hope of finding better treatments for people dealing with these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $119,880 |
| NIH project number | 5K99NS133478-02 |
| Project ID | NIH-10890865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions, particularly those involving skin or visceral organ inflammation.
✕Less likely to help
Patients with acute inflammatory conditions or those not affected by sensory neuron-related inflammation may not benefit from this research.
What this research studies
This research investigates the role of sensory neurons, particularly those that detect itch, in the development and progression of chronic inflammatory diseases. By using advanced genetic and viral techniques, the study aims to uncover how these neurons interact with the immune system and contribute to inflammation in various conditions. The goal is to better understand the mechanisms behind these interactions, which could lead to more effective treatments for patients suffering from inflammatory disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage or treat chronic inflammatory diseases.
How similar studies have gone: While the specific focus on pruriceptors in inflammatory diseases is relatively novel, similar research has shown promise in understanding the role of sensory neurons in other contexts.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Hill, Rose Z — Scripps Research Institute, the
- Study coordinator: Hill, Rose Z
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.