Understanding how sensory neuron excitation contributes to nerve pain from cancer treatment
The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy
['FUNDING_R01'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-10804246
This study is looking into why some cancer patients experience painful nerve damage from the chemotherapy drug paclitaxel, hoping to find new ways to help those who suffer from this side effect.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-10804246 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind paclitaxel-induced peripheral neuropathy (PIPN), a painful condition that affects cancer patients receiving paclitaxel. It focuses on how acute excitation of sensory neurons during treatment may lead to nerve damage and pain. By studying the cellular processes involved, the research aims to identify potential targets for new therapies that could alleviate this debilitating side effect. Patients experiencing acute pain during treatment may be particularly at risk for developing PIPN, making this research highly relevant.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are receiving paclitaxel and experiencing acute pain during their treatment.
Not a fit: Patients who are not undergoing paclitaxel treatment or those without acute pain during infusion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent or reduce nerve pain in cancer patients undergoing paclitaxel therapy.
How similar studies have performed: Previous research has indicated that understanding the mechanisms of drug-induced neuropathy can lead to effective interventions, suggesting this approach has potential for success.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, QING — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: YANG, QING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer