Understanding how sensory cells regenerate after nerve damage in zebrafish
Official title: Mechanisms of sensory hair cell reinnervation following lateral line cranial nerve damage in Danio rerio
Funded at Weill Medical Coll of Cornell Univ · NIH-11086072 · Data updated 2026-11-12
This study is looking at how zebrafish can regrow their hearing cells and nerves after injury, with the hope that understanding this process can help find new ways to treat hearing loss in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30DC021350-03 |
| Project ID | NIH-11086072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals suffering from sensorineural hearing loss due to damage to the auditory nerve.
✕Less likely to help
Patients with hearing loss caused by non-sensorineural factors, such as conductive hearing loss or structural abnormalities, may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the regeneration of sensory hair cells and their associated nerve fibers in zebrafish, a model organism for studying nerve regeneration. By examining the molecular signals that guide the growth of these nerves after injury, the study aims to uncover how these processes can be harnessed to restore hearing. The research involves isolating hair cells at various time points following nerve damage to analyze the changes in molecular cues that promote nerve growth and reinnervation. This approach could provide insights into potential therapies for hearing loss in humans.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sensorineural hearing loss by promoting nerve regeneration in the inner ear.
How similar studies have gone: Previous studies in zebrafish and other model organisms have shown promising results in understanding nerve regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Roy, Rohan — Weill Medical Coll of Cornell Univ
- Study coordinator: Roy, Rohan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.