Understanding how sensitive populations respond to DNA-damaging chemicals
Official title: Modeling the Responsiveness of Sensitive Populations to Genotoxic Agents Using DNA Repair Inhibitors
Funded at Litron Laboratories, LTD. · NIH-10734425 · Data updated 2026-11-12
This study is looking at how different people, especially those who are more sensitive to DNA damage, react to certain chemicals that can harm our DNA, with the goal of developing a quick test to help predict which chemicals might be risky for our health.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Litron Laboratories, LTD. NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $230,278 |
| NIH project number | 1R43ES035550-01 |
| Project ID | NIH-10734425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals from sensitive populations who may have varying DNA repair capacities.
✕Less likely to help
Patients who do not have any known sensitivities to DNA damage or are not part of sensitive populations may not benefit from this research.
What this research studies
This research investigates how different human populations, particularly those sensitive to DNA damage, respond to genotoxic agents. By using a specific human cell line and a range of DNA repair inhibitors, the study aims to create a high-throughput assay that can predict the potential for chemicals to cause DNA damage. This innovative approach focuses on understanding the variability in DNA repair capacity among individuals, which is crucial for assessing risks associated with exposure to various chemicals. The findings could lead to better safety assessments for new and existing substances.
Why it matters
Potential benefit: If successful, this research could improve safety evaluations for chemicals, ultimately protecting vulnerable populations from DNA damage.
How similar studies have gone: While the approach of using DNA repair inhibitors in this context is innovative, similar methodologies have shown promise in other areas of genetic toxicology.
Where this research is happening
-
Litron Laboratories, LTD.
Rochester, United States Active
Researchers
- Principal investigator: Dertinger, Stephen D — Litron Laboratories, LTD.
- Study coordinator: Dertinger, Stephen D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.