Understanding how Sema7a affects tooth development and health
Official title: SEMA7a regulation of tooth mineralization, root elongation, and innervation
Funded at Ohio State University · NIH-10943430 · Data updated 2026-11-12
This study is looking at how a specific signaling process helps young teeth grow strong and healthy, which could help us find better ways to treat tooth problems in kids and young adults.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $157,500 |
| NIH project number | 1R03DE033966-01 |
| Project ID | NIH-10943430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults who are experiencing dental development issues or have damaged teeth.
✕Less likely to help
Patients with fully developed teeth or those who do not have dental health concerns may not benefit from this research.
What this research studies
This research investigates the role of Sema7a signaling in the development of healthy molar teeth, focusing on processes like mineralization, root elongation, and sensory innervation. By studying mouse models, the research aims to uncover how disruptions in these processes can impact tooth health, particularly in young patients. The findings could provide insights into the cellular mechanisms that ensure the vitality of immature teeth, which is crucial for pediatric dental care. The ultimate goal is to improve treatment strategies for damaged or infected teeth in children and young adults.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for maintaining healthy teeth in children and young adults, especially those with dental issues.
How similar studies have gone: Previous research has shown promising results in understanding tooth development and signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Peters, Sarah — Ohio State University
- Study coordinator: Peters, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.