Understanding How Self-Cleaving RNA Molecules Work
Structure-Activity Based Mechanistic Insights into Cleavage Chemistry by Self-Cleaving Nucleolytic Ribozymes
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11117113
This project aims to understand how tiny RNA molecules, called ribozymes, cut other molecules, which is a fundamental process in biology.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11117113 on ClinicalTrials.gov |
What this research studies
Our bodies rely on many tiny molecules to function, including special RNA molecules called ribozymes that can cut other molecules. This project focuses on understanding the exact steps and structures these ribozymes use to perform their cutting action. We are looking closely at how their active sites are organized, how they activate certain chemical groups, and the role of metal ions like magnesium in their activity. By studying different types of ribozymes and their detailed structures, we hope to uncover the general rules governing how these important biological cutters work.
Who could benefit from this research
Good fit: This foundational biological research does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate therapeutic interventions would not directly benefit from this basic science investigation.
Why it matters
Potential benefit: A deeper understanding of how these RNA molecules function could eventually help in developing new ways to target diseases where these processes are involved, such as viral infections.
How similar studies have performed: While the specific mechanisms of many ribozymes are still being uncovered, previous studies have successfully used structural and biochemical methods to understand other catalytic RNA molecules.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PATEL, DINSHAW J — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: PATEL, DINSHAW J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.