Understanding how selenium protects our cells
Selenoprotein-independent biological roles for selenium in selenium deficiency and excess
This project explores a new way selenium works in our bodies, beyond its known functions, to protect cells and improve energy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11114007 on NIH RePORTER |
What this research studies
Selenium is a vital nutrient known for its antioxidant properties, often linked to special proteins called selenoproteins. However, we've found that selenium can also act much faster as an antioxidant by helping our cells create a key molecule called ubiquinol, which is crucial for energy production and protecting against damage. This new understanding could explain why too little selenium is harmful and open doors for new treatments. We are looking into how this process helps protect heart muscle cells from damage and improves cell energy.
Who could benefit from this research
Good fit: Patients who might eventually benefit from this foundational work include those with conditions related to selenium deficiency, oxidative stress, or heart muscle damage.
Not a fit: Patients seeking immediate clinical treatment or direct participation in a human trial would not benefit from this basic science project at its current stage.
Why it matters
Potential benefit: If successful, this work could lead to new ways to use selenium to protect cells, especially heart cells, and develop new treatments for conditions related to selenium imbalance or cellular damage.
How similar studies have performed: This project builds upon the discovery of a novel biological mechanism for selenium, suggesting a new pathway for its antioxidant and energy-boosting effects.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Kim, Dohoon — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kim, Dohoon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.