Understanding how seizures can lead to breathing problems and sudden death in epilepsy
The neural circuitry of seizure-induced apnea and SUDEP
This study is looking into how seizures can lead to breathing problems that might cause sudden death in people with epilepsy, and it's for anyone interested in understanding how we can help prevent these dangerous situations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11109438 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind Sudden Unexpected Death in Epilepsy (SUDEP), particularly focusing on how seizures can cause respiratory arrest, known as seizure-induced apnea (SIA). Using various mouse models, the study aims to identify the neural circuits involved in SIA and how they contribute to fatal outcomes during seizures. The researchers will employ techniques like electrophysiology and genetic mapping to explore the excitability of specific brain regions and their role in respiratory control during seizures. The ultimate goal is to uncover potential interventions that could prevent these life-threatening events in patients with epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy, particularly those who experience refractory seizures or have a history of SUDEP.
Not a fit: Patients with epilepsy who do not experience seizures or have well-controlled seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies to prevent sudden death in patients with epilepsy by addressing the underlying causes of seizure-induced apnea.
How similar studies have performed: While the specific approach of this research is novel, there is growing evidence from other studies indicating that understanding the neural mechanisms of SUDEP can lead to meaningful advancements in prevention strategies.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Wenker, Ian Christopher — University of Virginia
- Study coordinator: Wenker, Ian Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.