Understanding how sedatives affect delirium in children
Pharmacokinetics of sedatives – Understanding a modifiable risk factor for pediatric delirium
This study is looking at how certain sedative medications, especially benzodiazepines, might affect the thinking and behavior of critically ill children, using a new tool to help spot signs of delirium, so doctors can make better choices about how to safely sedate young patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10667532 on NIH RePORTER |
What this research studies
This research investigates the relationship between sedative medications and the development of delirium in children. By using a newly developed screening tool, the Cornell Assessment of Pediatric Delirium, the study aims to identify how different sedatives, particularly benzodiazepines, may contribute to cognitive changes in critically ill pediatric patients. The research will involve multiple centers and will analyze pharmacokinetic data to understand how drug clearance and serum concentrations influence delirium risk. This information could help clinicians make informed decisions about sedation practices in young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-21 who are critically ill and receiving sedative medications.
Not a fit: Patients who are not critically ill or who are not receiving sedative medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved sedation practices that reduce the incidence of delirium in critically ill children.
How similar studies have performed: Previous research has indicated that sedative use can impact cognitive function, but this specific investigation into pediatric delirium and sedative pharmacokinetics is relatively novel.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Bell, Michael J — Children's Research Institute
- Study coordinator: Bell, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.