Understanding how secondary bile acids contribute to esophageal cancer development
The Role of Secondary Bile Acids in Gastro-Esophageal Neoplasia
This study is looking at how certain substances made by gut bacteria might affect the development of esophageal cancer and Barrett's esophagus, focusing on specific cells in the area where the esophagus meets the stomach, to find new ways to prevent or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10909180 on NIH RePORTER |
What this research studies
This research investigates the role of secondary bile acids produced by gut bacteria in the development of esophageal adenocarcinoma and Barrett's esophagus. It focuses on stem and progenitor cells at the gastroesophageal junction, which are believed to be key players in cancer initiation. The study employs a mouse model to explore how these bile acids influence cancer progression and the surrounding cellular environment. By identifying the mechanisms involved, the research aims to uncover potential therapeutic targets for preventing or treating these cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Barrett's esophagus or those at high risk for esophageal adenocarcinoma.
Not a fit: Patients with other types of esophageal cancer unrelated to Barrett's esophagus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating esophageal cancer, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of bile acids in cancer development, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Abrams, Julian — Columbia University Health Sciences
- Study coordinator: Abrams, Julian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.