Understanding how Scribble affects blood vessel formation and cell connections
Official title: Elucidating the role of Scribble in angiogenic symmetry breaking and adherens junction remodeling
Funded at University of California, San Francisco · NIH-11051766 · Data updated 2026-11-12
This study is looking at a protein called Scribble to see how it helps cells create new blood vessels, which is important for both healthy growth and stopping tumors from getting too much blood supply, so it could lead to better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,081 |
| NIH project number | 5F31HL172606-02 |
| Project ID | NIH-11051766 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve abnormal blood vessel growth, such as cancer or chronic wounds.
✕Less likely to help
Patients with stable conditions that do not involve angiogenesis or vascular issues may not benefit from this research.
What this research studies
This research investigates the role of a protein called Scribble in the process of angiogenesis, which is the formation of new blood vessels. It aims to understand how Scribble influences the behavior of endothelial cells, particularly how they break symmetry to migrate and form new vessels. By studying the interactions of Scribble with other proteins involved in cell adhesion, the research seeks to uncover new molecular regulators that could impact both normal vascular development and tumor growth. Patients may benefit from insights gained into how to promote healthy blood vessel formation or inhibit unwanted vascularization in tumors.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing healthy blood vessel growth or preventing tumor vascularization.
How similar studies have gone: Previous research has shown promising results in understanding angiogenesis, but the specific role of Scribble in this process is still being explored.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Mayo, Lakyn Nicole — University of California, San Francisco
- Study coordinator: Mayo, Lakyn Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.