Understanding how Schwann cells interact with axons in the nervous system
Mechanisms of Axon-Schwann cell interactions
This study is looking at how certain cells in your nerves work together to help repair damage and keep your nerves healthy, using zebrafish to learn more about the genes involved, which could lead to better treatments for nerve injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11083714 on NIH RePORTER |
What this research studies
This research investigates the interactions between Schwann cells and axons in the peripheral nervous system, focusing on how these interactions affect myelination and nerve repair. By studying zebrafish models, the research aims to uncover the genetic and molecular mechanisms that regulate Schwann cell development and myelination. The team has identified specific genetic factors, such as Dock1, that may play a crucial role in nerve repair after injury. This work could lead to new insights into treatments for conditions that involve nerve damage and demyelination.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the peripheral nervous system, particularly those experiencing nerve injuries or demyelination.
Not a fit: Patients with central nervous system disorders or those who do not have peripheral nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance nerve repair and myelination, potentially improving outcomes for patients with nerve injuries or demyelinating diseases.
How similar studies have performed: Previous research has shown promise in understanding Schwann cell functions and their role in nerve repair, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Monk, Kelly R — Oregon Health & Science University
- Study coordinator: Monk, Kelly R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.