Understanding how Schwann cells help nerves heal after injury
Official title: Schwann Cell Reprogramming after Nerve Injury
Funded at University of Wisconsin-Madison · NIH-11122208 · Data updated 2026-11-12
This study is looking at how special cells called Schwann cells can be trained to help heal damaged nerves better, especially for older people or those with long-term nerve issues, to find new ways to speed up recovery and improve healing for anyone with nerve injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $475,401 |
| NIH project number | 5R01NS130566-03 |
| Project ID | NIH-11122208 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced peripheral nerve injuries, especially older adults or those with chronic conditions affecting nerve regeneration.
✕Less likely to help
Patients with acute nerve injuries that are not expected to require advanced therapeutic interventions may not benefit from this research.
What this research studies
This research investigates the role of Schwann cells in the regeneration of peripheral nerves after injury. It focuses on how these cells can be reprogrammed to enhance their ability to support nerve repair, particularly in older individuals or those with chronic nerve damage. By exploring the genetic and epigenetic factors that influence Schwann cell behavior, the study aims to identify new strategies to accelerate the healing process and improve outcomes for patients with nerve injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from nerve injuries, enhancing their recovery and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding Schwann cell behavior and nerve regeneration, indicating that this approach has potential for success.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Svaren, John P — University of Wisconsin-Madison
- Study coordinator: Svaren, John P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.