Understanding how Schwann cells develop their structure and function
Official title: The role of the extracellular matrix in establishing Schwann cell polarity
Funded at University of California, San Francisco · NIH-10854726 · Data updated 2026-11-12
This study looks at how a special support structure around nerve cells helps Schwann cells, which are important for protecting and insulating nerves, to grow and position themselves correctly, so we can better understand how to support nerve health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,009 |
| NIH project number | 5F31NS130956-02 |
| Project ID | NIH-10854726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting peripheral nerve function or those at risk for demyelinating diseases.
✕Less likely to help
Patients with non-neurological conditions or those whose nerve function is not impacted may not benefit from this research.
What this research studies
This research investigates the role of the extracellular matrix in the development of Schwann cell polarity, which is crucial for the proper functioning of peripheral nerves. The study focuses on how Schwann cells, which are essential for myelination, establish their orientation and structure in relation to the extracellular matrix. By examining the signaling pathways involved, particularly the role of collagen-IV and its receptor integrin alpha2, the research aims to uncover the mechanisms that regulate Schwann cell behavior during nerve development.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating demyelinating diseases and improving nerve repair strategies.
How similar studies have gone: Previous research has shown that understanding the extracellular matrix's role in cell behavior can lead to significant advancements in nerve repair and regeneration.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Lillis, Monique — University of California, San Francisco
- Study coordinator: Lillis, Monique
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.