Understanding how Schwann cells develop their structure and function
The role of the extracellular matrix in establishing Schwann cell polarity
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10854726
This study looks at how a special support structure around nerve cells helps Schwann cells, which are important for protecting and insulating nerves, to grow and position themselves correctly, so we can better understand how to support nerve health.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10854726 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the extracellular matrix in the development of Schwann cell polarity, which is crucial for the proper functioning of peripheral nerves. The study focuses on how Schwann cells, which are essential for myelination, establish their orientation and structure in relation to the extracellular matrix. By examining the signaling pathways involved, particularly the role of collagen-IV and its receptor integrin alpha2, the research aims to uncover the mechanisms that regulate Schwann cell behavior during nerve development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting peripheral nerve function or those at risk for demyelinating diseases.
Not a fit: Patients with non-neurological conditions or those whose nerve function is not impacted may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating demyelinating diseases and improving nerve repair strategies.
How similar studies have performed: Previous research has shown that understanding the extracellular matrix's role in cell behavior can lead to significant advancements in nerve repair and regeneration.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LILLIS, MONIQUE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: LILLIS, MONIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.