Understanding how SARS-CoV-2 interacts with the human body to improve antiviral treatments
Official title: Emerging mechanisms of viral gene regulation from battles between host and SARS-CoV-2
Funded at Johns Hopkins University · NIH-10894106 · Data updated 2026-11-12
This study is looking at how the SARS-CoV-2 virus interacts with our bodies to find new ways to fight it, which could help create better treatments for people dealing with COVID-19.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $489,658 |
| NIH project number | 5DP2AI177906-02 |
| Project ID | NIH-10894106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals affected by COVID-19 or those at high risk for severe outcomes from the virus.
✕Less likely to help
Patients who are not infected with SARS-CoV-2 or those with mild cases that do not require antiviral treatment may not receive direct benefits from this research.
What this research studies
This research investigates the complex interactions between the SARS-CoV-2 virus and the human host to uncover new mechanisms of viral gene regulation. By focusing on the viral life cycle and the host's immune response, the study aims to identify novel targets for antiviral therapies. The approach includes analyzing the virus's unique proofreading mechanisms and how they affect the effectiveness of current treatments. Patients may benefit from insights that lead to the development of more effective antiviral drugs.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative antiviral treatments for COVID-19 and future coronavirus infections.
How similar studies have gone: Other research has shown promise in targeting viral-host interactions for antiviral development, indicating that this approach could yield significant advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Liu, Chang — Johns Hopkins University
- Study coordinator: Liu, Chang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.