Understanding how SARS-CoV-2 hijacks human cells to evade the immune system
Mechanism-based Targeting of the RNA Processing Machinery of SARS-CoV-2
This study is looking at how the SARS-CoV-2 virus sneaks into our cells and hides from our immune system, with the hope of finding new ways to create treatments for COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11177199 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the SARS-CoV-2 virus invades human cells and avoids detection by the immune system. It focuses on a specific protein complex that modifies the viral RNA to mimic the host's own RNA, allowing the virus to replicate undetected. By studying this process at an atomic level, researchers aim to identify potential therapeutic targets that could disrupt the virus's ability to hijack cellular machinery. The ultimate goal is to develop effective treatments for COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with SARS-CoV-2 or those at high risk of severe COVID-19 outcomes.
Not a fit: Patients who are not infected with SARS-CoV-2 or those who have already recovered from COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral therapies that effectively combat COVID-19 by targeting the virus's ability to evade the immune response.
How similar studies have performed: Previous research has shown success in targeting viral mechanisms in other infections, suggesting that this approach may yield promising results for COVID-19 as well.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Gupta, Yogesh K — University of Texas Hlth Science Center
- Study coordinator: Gupta, Yogesh K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.