Understanding how SARS-CoV-2 enters cells and finding ways to block it
Mechanism and Inhibition of SARS-CoV-2 Entry
This study is looking at how the COVID-19 virus gets into our cells and is testing different treatments that could stop this process, so it’s aimed at helping anyone interested in finding better ways to fight COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10874782 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the SARS-CoV-2 virus, responsible for COVID-19, enters human cells. It focuses on the interaction between the virus's spike protein and the ACE2 receptor on cell surfaces, which is crucial for viral entry. The study employs advanced imaging techniques to track the entry process of the virus and identify potential therapeutic targets to inhibit this process. By using a modified virus that mimics SARS-CoV-2, researchers aim to test various inhibitors, including antibodies and small molecules, to find effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for COVID-19 infection, including those with underlying health conditions or compromised immune systems.
Not a fit: Patients who have already recovered from COVID-19 and have developed immunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that prevent SARS-CoV-2 from entering cells, potentially reducing COVID-19 infections.
How similar studies have performed: Other research has shown promise in targeting viral entry mechanisms, indicating that this approach could yield significant advancements in COVID-19 treatment.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Whelan, Sean Pj — Washington University
- Study coordinator: Whelan, Sean Pj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.