Understanding how SARS-CoV-2 behaves and affects individual cells
Tracking SARS-CoV-2 one molecule at a time: Spatiotemporal investigation of coronavirus replication dynamics and host response in single cells in vitro and in vivo
This study is looking at how the SARS-CoV-2 virus behaves when it infects our cells and how our immune system responds, with the goal of finding better ways to treat COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11009999 on NIH RePORTER |
What this research studies
This research investigates the replication dynamics of the SARS-CoV-2 virus and how it interacts with host cells at a very detailed level. By using advanced techniques to observe single cells, the researchers aim to uncover how the virus enters cells, begins to replicate, and how the host's immune response varies among different cells. This approach allows for a more precise understanding of the virus's behavior and the diverse responses it triggers in the body, which could lead to better treatment strategies for COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals infected with SARS-CoV-2, particularly those experiencing varying degrees of COVID-19 symptoms.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and interventions for COVID-19 by providing insights into the virus's behavior and its impact on different individuals.
How similar studies have performed: Other research has shown success in using single-cell analysis to understand viral infections, making this approach promising yet still innovative in the context of SARS-CoV-2.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Rice, Charles M — Rockefeller University
- Study coordinator: Rice, Charles M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.