Understanding how SARS-CoV-2 affects multiple organs in the body
Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicity
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10846284
This study is looking at how COVID-19 affects different organs in the body, not just the lungs, by using mice to understand the changes that happen and how they might lead to serious health problems for people with the virus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10846284 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of SARS-CoV-2 on various vital organs beyond the respiratory system, focusing on how the virus causes systemic toxicity. Using a mouse model, the study examines metabolic and epigenetic changes in organs affected by the virus, which may lead to severe complications. The researchers aim to uncover the mechanisms behind organ dysfunction and the resulting health issues in COVID-19 patients, providing insights into the broader impacts of the virus on the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe COVID-19 symptoms or complications affecting multiple organ systems.
Not a fit: Patients who have not contracted COVID-19 or those with mild symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of COVID-19 related organ complications, potentially improving patient outcomes.
How similar studies have performed: Other research has shown that understanding systemic effects of viral infections can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEB, ARJUN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: DEB, ARJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.