Understanding how sample handling affects brain cancer biomarker testing
Influence of Pre-Analytical Factors in Globlastoma MGMT Promoter Methylation Biomarker Assay
This study is looking at ways to make a test for a gene related to glioblastoma, a tough type of brain cancer, more accurate, so that doctors can better choose the right treatments for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10871887 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a severe brain cancer, and aims to improve the accuracy of a specific biomarker test related to the MGMT gene. The study investigates how various factors during sample collection and processing can influence the results of this test, which is crucial for determining the best treatment options for patients. By developing advanced tools for better sample preparation and analysis, the research seeks to establish standardized protocols that can enhance the reliability of biomarker assessments in glioblastoma. This could lead to more personalized and effective treatment strategies for patients diagnosed with this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing treatment or considering participation in clinical trials.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate testing for glioblastoma patients, allowing for better-informed treatment decisions and potentially improved outcomes.
How similar studies have performed: Previous research has shown that improving pre-analytical processes can enhance biomarker testing reliability, suggesting that this approach has potential for success.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Bomsztyk, Karol — University of Washington
- Study coordinator: Bomsztyk, Karol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.