Understanding how SAMHD1 helps the immune system fight HIV
Official title: Biochemistry of SAMHD1-mediated innate immunity responses
Funded at University of Texas Hlth Science Center · NIH-11124942 · Data updated 2026-11-12
This study is looking at how a protein called SAMHD1 helps protect certain immune cells from HIV by managing important building blocks for DNA, which could lead to new ways to boost our immune response against the virus.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | June 25, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $556,253 |
| NIH project number | 5R37AI136697-06 |
| Project ID | NIH-11124942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
✕Less likely to help
Patients who are not infected with HIV or who do not have risk factors for HIV may not benefit from this research.
What this research studies
This research investigates the role of SAMHD1, a human immune factor, in preventing HIV infection in certain immune cells. It focuses on how SAMHD1 regulates the levels of deoxynucleotides, which are crucial for DNA repair and cellular functions, and how this regulation impacts antiviral immunity. By exploring the mechanisms of SAMHD1's action, the research aims to uncover new insights into how immune cells can effectively respond to HIV, potentially leading to novel therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against HIV, improving outcomes for patients with HIV/AIDS.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of antiviral immunity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Ivanov, Dmitri N — University of Texas Hlth Science Center
- Study coordinator: Ivanov, Dmitri N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.