Understanding how SAMHD1 affects HIV infection in immune cells
SAMHD1 mediated dNTP regulation and HIV in myeloid cells
This study is looking at how a protein called SAMHD1 helps control the building blocks that viruses like HIV need to multiply, especially in immune cells that don’t divide, with the hope of finding new ways to treat HIV infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11082290 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called SAMHD1 in regulating the levels of dNTPs, which are essential building blocks for viral replication, particularly in immune cells like macrophages that do not divide. The study aims to uncover how SAMHD1 not only breaks down dNTPs but also inhibits their production, thereby limiting HIV-1 replication in these cells. By exploring the molecular mechanisms involved, the research seeks to provide insights that could lead to new therapeutic strategies against HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those with a focus on immune responses involving macrophages.
Not a fit: Patients who are not infected with HIV or those with conditions unrelated to HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the immune response against HIV by targeting dNTP regulation.
How similar studies have performed: Previous research has shown promising results in understanding the role of SAMHD1 in HIV replication, indicating that this approach has potential for significant advancements.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Kim, Baek — Emory University
- Study coordinator: Kim, Baek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.