Understanding how SAMD1 affects blood cell development
Defining Mechanisms of SAMD1 in Hematopoiesis
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10996709
This study is looking at how a protein called SAMD1 helps blood cells grow from their early stem cell stages, which could help us understand and find better treatments for blood diseases like leukemia and anemia.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10996709 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the SAMD1 protein in the development of blood cells from hematopoietic stem and progenitor cells (HSPCs). By using advanced techniques like CRISPR-Cas9 to modify human cells and conducting experiments in mice, the researchers aim to uncover how SAMD1 influences blood cell formation and function. The findings could provide insights into blood-related diseases such as leukemia and anemia, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with blood disorders such as acute myeloid leukemia or chronic anemia.
Not a fit: Patients with non-blood-related conditions or those who do not have any hematological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for blood disorders, including acute myeloid leukemia and chronic anemia.
How similar studies have performed: Other research has shown promising results in understanding blood cell development, but the specific role of SAMD1 in this context is relatively novel.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHAEFER, MEG — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: SCHAEFER, MEG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.