Understanding how Salmonella infections can lead to chronic arthritis
Official title: Role of ZBP1 in pathogenesis of Salmonella biofilms
Funded at Research Inst of Fox Chase Can Ctr · NIH-11074044 · Data updated 2026-11-12
This study is looking at a protein from Salmonella that might cause inflammation leading to Reactive Arthritis after an infection, and it aims to understand how this protein interacts with bacterial DNA to trigger immune responses, which could help find new ways to prevent or treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 11, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $838,667 |
| NIH project number | 5R01AI171568-03 |
| Project ID | NIH-11074044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced Salmonella infections and are at risk of developing Reactive Arthritis.
✕Less likely to help
Patients who have not had Salmonella infections or those who do not develop Reactive Arthritis may not benefit from this research.
What this research studies
This research investigates the role of a specific protein from Salmonella, known as curli, in causing inflammation that may lead to Reactive Arthritis after an infection. The study focuses on how curli interacts with bacterial DNA to trigger immune responses that result in chronic pain and inflammation. By examining these interactions, researchers aim to uncover the underlying mechanisms that cause some individuals to develop long-term complications after a Salmonella infection. This could provide insights into potential therapeutic targets for preventing or treating Reactive Arthritis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Reactive Arthritis in patients who have had Salmonella infections.
How similar studies have gone: Previous research has shown that understanding the immune response to bacterial infections can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
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Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Balachandran, Siddharth — Research Inst of Fox Chase Can Ctr
- Study coordinator: Balachandran, Siddharth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.