Understanding how Salmonella competes with gut bacteria
Official title: Applied Metatranscriptomics and Metatranslatomics to identify new mechanisms of Salmonella-microbiota competition
Funded at University of California, San Diego · NIH-11090491 · Data updated 2026-11-12
This study looks at how the Salmonella bacteria interact with the good bacteria in our gut, aiming to understand how Salmonella takes over and what that means for our gut health, which could lead to better treatments for infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 16, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $178,331 |
| NIH project number | 5R21AI186034-02 |
| Project ID | NIH-11090491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with gastrointestinal issues or those at risk of Salmonella infections.
✕Less likely to help
Patients with no gastrointestinal concerns or those not at risk for Salmonella infections may not receive any benefit from this research.
What this research studies
This research investigates the interactions between the pathogen Salmonella enterica and the gut microbiota, focusing on how Salmonella establishes itself in the gut and outcompetes beneficial bacteria. By using advanced techniques like metagenomics, metatranscriptomics, and metatranslatomics, the study aims to uncover the specific mechanisms of competition and resource allocation in the gut environment. Patients may benefit from insights gained about gut health and potential new treatments for infections caused by Salmonella.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating Salmonella infections by enhancing our understanding of gut microbiota interactions.
How similar studies have gone: Other research has shown success in understanding microbial interactions in the gut, making this approach promising yet still exploring novel aspects.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Raffatellu, Manuela — University of California, San Diego
- Study coordinator: Raffatellu, Manuela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.