Understanding how Salmonella causes enteric fever
The Pathogenesis of Enteric Fever
This study is looking at how the bacteria that cause enteric fever interact with our immune system, using special mice that mimic human responses, to find new ways to treat this serious illness that affects many people around the world.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10766134 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Salmonella Typhi and Paratyphi cause enteric fever, a serious illness affecting millions worldwide. Using a novel animal model with humanized mice, the study explores how these bacteria interact with human immune cells, particularly macrophages, to persist and cause disease. The researchers aim to identify key factors that contribute to the bacteria's virulence and survival, which could lead to new treatment strategies. By analyzing the immune response and bacterial behavior in this model, the research seeks to uncover potential therapeutic targets for chronic infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with enteric fever or are at high risk of infection due to travel or exposure.
Not a fit: Patients with non-enteric fever related illnesses or those who do not have a history of Salmonella infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for enteric fever, potentially reducing the incidence and severity of this disease.
How similar studies have performed: Previous research has shown success in using animal models to study bacterial infections, indicating that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Fang, Ferric C — University of Washington
- Study coordinator: Fang, Ferric C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.