Understanding how Salmonella bacteria survive inside the body
Molecular determinants of oxidative stress in Salmonella pathogenesis
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11171699
This project looks at how Salmonella bacteria cause severe infections, especially in people with weakened immune systems like those with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11171699 on ClinicalTrials.gov |
What this research studies
Salmonella infections can be very dangerous, especially for vulnerable individuals such as the very young, very old, or those with weakened immune systems. Our immune cells try to fight these bacteria by attacking them with harmful oxygen molecules. This project explores how Salmonella changes its metabolism to protect itself from these attacks and continue to grow inside the body. By understanding these survival strategies, we hope to find new ways to stop these life-threatening infections.
Who could benefit from this research
Good fit: This foundational work does not directly involve patient participation but aims to benefit individuals susceptible to severe Salmonella infections, such as the very young, very old, or those with weakened immune systems like HIV patients.
Not a fit: Patients not at risk for severe, systemic Salmonella infections, or those with healthy immune systems, may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target Salmonella's survival mechanisms, making infections less severe and easier to clear, particularly for people with compromised immune systems.
How similar studies have performed: Previous work has shown that Salmonella adapts its metabolism to survive within host cells, and this project builds upon recent crucial observations made by the researchers regarding anaerobic respiration.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAZQUEZ-TORRES, ANDRES — UNIVERSITY OF COLORADO DENVER
- Study coordinator: VAZQUEZ-TORRES, ANDRES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus