Understanding how Salmonella bacteria survive in the body during infections
Official title: Molecular determinants of oxidative stress in Salmonella pathogenesis
Funded at University of Colorado Denver · NIH-10882502 · Data updated 2026-11-12
This study is looking at how Salmonella bacteria manage to survive and avoid being killed by our immune system, especially when they get inside certain immune cells, and it aims to find ways to help prevent and treat infections caused by these bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 16, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $505,126 |
| NIH project number | 2R01AI136520-06A1 |
| Project ID | NIH-10882502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals, especially young children, the elderly, and immunocompromised patients, who are at higher risk for severe Salmonella infections.
✕Less likely to help
Patients who are not at risk for Salmonella infections or those with unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Salmonella bacteria resist the immune response, particularly focusing on how they survive in phagocytic cells that attack them. The study examines the role of anaerobic respiration and specific gene products that help Salmonella thrive in hostile environments, such as those created by reactive oxygen species. By using animal models and cell cultures, researchers aim to uncover the metabolic adaptations that allow these bacteria to evade destruction and cause disease. This knowledge could lead to better strategies for preventing and treating infections caused by Salmonella.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for Salmonella infections, particularly in vulnerable populations.
How similar studies have gone: Previous research has shown success in understanding bacterial survival mechanisms, making this approach promising for uncovering new insights into Salmonella pathogenesis.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Vazquez-Torres, Andres — University of Colorado Denver
- Study coordinator: Vazquez-Torres, Andres
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.