Understanding how Salmonella bacteria manipulate immune responses during infection
The Molecular Mechanism and Pathophysiology of Robust STAT3 Signaling During Oral Salmonella Typhimurium Infection
['FUNDING_FELLOWSHIP'] · DUKE UNIVERSITY · NIH-11019700
This study looks at how a germ called Salmonella Typhimurium tricks our immune system to survive longer during an infection, focusing on a special protein that helps it do this, and the findings could help people who get sick from this bacteria.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11019700 on ClinicalTrials.gov |
What this research studies
This research investigates how Salmonella Typhimurium, a common cause of gastroenteritis, affects the immune system during infection. It focuses on a specific protein, SarA, that the bacteria use to enhance their survival by prolonging the activation of a signaling pathway called STAT3 in host cells. By studying the molecular mechanisms involved, the research aims to uncover how this manipulation leads to anti-inflammatory responses, which could help the bacteria evade the immune system. Patients with infections caused by Salmonella may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals experiencing acute gastroenteritis caused by Salmonella Typhimurium.
Not a fit: Patients with infections caused by other pathogens or those without gastrointestinal symptoms may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against Salmonella infections.
How similar studies have performed: Previous research has shown that understanding bacterial manipulation of host immune responses can lead to significant advancements in treatment strategies, indicating potential success for this approach.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAGGIOLI, MARGARET RYAN — DUKE UNIVERSITY
- Study coordinator: GAGGIOLI, MARGARET RYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection