Understanding how Salmonella bacteria cause infections.
Analysis of regulatory networks in Salmonella pathogenesis.
This study is looking at how Salmonella bacteria make people with weakened immune systems, like those with HIV, sick, and it's trying to find new ways to help prevent or treat these infections by understanding how the bacteria interact with our cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10899535 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Salmonella bacteria, particularly the Typhimurium serovar, cause infections and complications in individuals with weakened immune systems, such as those with HIV. The team is exploring how specific proteins in the bacteria interact with host cells to trigger virulence, focusing on a newly discovered regulatory system that controls these interactions. By studying these processes, the research aims to uncover potential targets for new treatments or preventive measures against Salmonella infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems, such as those living with HIV or other conditions that affect neutrophil or CD4 T cell function.
Not a fit: Patients with healthy immune systems or those not affected by Salmonella infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Salmonella infections, particularly in immunocompromised patients.
How similar studies have performed: Previous research has shown success in understanding bacterial pathogenesis through similar regulatory network analyses, indicating a promising approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Vazquez-Torres, Andres — University of Colorado Denver
- Study coordinator: Vazquez-Torres, Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.