Understanding how salivary glands maintain and repair themselves
Salivary gland ionocyte organization and function during homeostasis, repair, and disease
This study is looking at special cells in your salivary glands that help keep your saliva flowing and your body balanced, to better understand how they work in both healthy and sick conditions, which could lead to new treatments for salivary gland problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11094912 on NIH RePORTER |
What this research studies
This research investigates the organization and function of specific cells in the salivary glands that are crucial for maintaining saliva production and ion balance. By using advanced techniques like lineage tracing and RNA sequencing, the study aims to identify how these cells behave during normal conditions, repair processes, and disease states. Patients may benefit from insights into how salivary gland dysfunction can lead to various health issues, potentially guiding future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing salivary gland disorders or related diseases.
Not a fit: Patients without any salivary gland issues or those under 21 years old may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to salivary gland dysfunction.
How similar studies have performed: Other research has shown promising results in understanding salivary gland function and its implications for health, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Makarenkova, Helen P. — Scripps Research Institute, the
- Study coordinator: Makarenkova, Helen P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.