Understanding how S100A9 contributes to brain metastasis in lung cancer
Official title: Mechanisms of S100A9-mediated brain metastasis
Funded at Columbia University Health Sciences · NIH-10982109 · Data updated 2026-11-12
This study is looking at how a protein called S100A9 affects the spread of lung cancer to the brain in patients with a specific type of lung cancer, hoping to find new ways to improve treatment and help those facing this challenge.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 12, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $164,500 |
| NIH project number | 1R56CA286906-01A1 |
| Project ID | NIH-10982109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with EGFR-mutant lung cancer who are at risk of developing brain metastasis.
✕Less likely to help
Patients with lung cancer who do not have EGFR mutations or those without brain metastasis may not benefit from this research.
What this research studies
This research investigates the role of S100A9 in the development of brain metastasis in patients with EGFR-mutant lung cancer. It aims to uncover the molecular mechanisms that lead to aggressive brain metastasis and therapy resistance. By utilizing advanced techniques like ATAC sequencing, the study will explore how S100A9 expression is regulated and its impact on cancer progression. The ultimate goal is to identify new therapeutic targets to improve treatment outcomes for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for brain metastasis in lung cancer patients, potentially improving survival rates.
How similar studies have gone: Previous studies have shown promising results in targeting molecular mechanisms related to cancer metastasis, suggesting that this approach could be effective.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Acharyya, Swarnali — Columbia University Health Sciences
- Study coordinator: Acharyya, Swarnali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.