Understanding how RUNX1 controls blood cell development
Official title: Mechanisms of RUNX1 transcriptional control in hematopoiesis
Funded at Albert Einstein College of Medicine · NIH-10944073 · Data updated 2026-11-12
This study is looking at how a gene called RUNX1 affects the development of blood cells and could help us understand blood disorders like familial platelet disorder and certain cancers, with the hope that it will lead to better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $688,800 |
| NIH project number | 1R01HL174948-01 |
| Project ID | NIH-10944073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with familial platelet disorder or those at risk for myeloid malignancies due to RUNX1 mutations.
✕Less likely to help
Patients without RUNX1-related blood disorders or those not genetically predisposed to myeloid malignancies may not benefit from this research.
What this research studies
This research investigates the role of the RUNX1 gene in blood cell development and its impact on conditions like familial platelet disorder and myeloid malignancies. By using advanced techniques to rapidly remove RUNX1 proteins, researchers aim to uncover how RUNX1 influences gene expression in blood cells. This approach allows for a more precise understanding of the mechanisms behind blood cell production and function, which could lead to new insights into related diseases. Patients may benefit from findings that could improve diagnosis and treatment options for blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with blood disorders linked to RUNX1 mutations.
How similar studies have gone: Previous research has successfully utilized similar genetic manipulation techniques to study transcription factors, indicating potential for success in this approach.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Stengel, Kristy — Albert Einstein College of Medicine
- Study coordinator: Stengel, Kristy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.