Understanding how RSV proteins affect the immune response
Mechanisms of Host Response Modulation by RSV Non-Structural Proteins
This study is looking at how certain proteins from the respiratory syncytial virus (RSV) affect the immune system, with the goal of finding new ways to help protect young children from serious RSV infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10873145 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins from the respiratory syncytial virus (RSV) in modulating the body's immune response. By studying how these proteins interact with the host's genetic material, the research aims to uncover mechanisms that allow RSV to evade the immune system and cause severe respiratory infections. The approach involves advanced cell culture techniques and molecular biology methods to analyze the effects of RSV proteins on immune gene expression. The findings could lead to new strategies for preventing or treating RSV infections in vulnerable populations, particularly children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are at risk for severe RSV infections.
Not a fit: Patients who are not affected by RSV or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive measures for RSV infections, particularly in young children.
How similar studies have performed: Previous research has shown that understanding viral mechanisms can lead to significant advancements in treatment options, suggesting potential success for this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Leung, Daisy W — Washington University
- Study coordinator: Leung, Daisy W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.